DegronMD

Uniprot ID: P54278

Source protein: Mismatch repair endonuclease PMS2

Source gene: PMS2

Class: DEG_SCF_TRCP1_1

Location: 493:499

E3 ligase: BTRC

DEGRON score: 0.9938

ASA_SCORE: 76.3429

COIL: 0.8571

CONS_SCORE: 0.2082

DSS_SCORE: 0.7092

HELIX: 0.0777

FCONS_SCORE: 1.0094

RIG_SCORE: 0.5481

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V501M	TCGA-BR-8081	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	0.2778
p.V501M	DO38795	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.2778
p.T485A	TCGA-EY-A1GK	UCEC	TCGA	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485A	TCGA-VQ-A91K	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485A	DO51785	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485A	DO42985	UCEC	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.S494L	TCGA-HU-A4G9	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	0.7667
p.S494L	DO47789	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.7667
p.E489K	TCGA-W3-A824	SKCM	TCGA	DSGHGST	DEG_SCF_TRCP1_1	0.2222
p.E489K	DO51271	SKCM	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.2222
p.T485K	DO228483	BRCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485K	DO229010	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485K	DO229013	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485K	DO229003	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485K	DO231140	LAML	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485K	DO231075	LUSC	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.D483E	DO233778	GACA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	0.0556
p.T485M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.T485M	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.5556
p.S500C	SIDM00690	Head and Neck Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.3056
p.S500C	ACH-002251	Head and Neck Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	0.3056
p.S500C	JHU-029	upper_aerodigestive_tract	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.3056
p.E504G	SIDM00538	Esophageal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504G	ACH-001497	Esophageal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504G	ESO51	oesophagus	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504Q	SIDM00826	Colorectal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504Q	SIDM00823	Colorectal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504Q	ACH-000253	Colon/Colorectal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504Q	ACH-001039	Colon/Colorectal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E504Q	COLO-205	large_intestine	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.1944
p.E491K	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.2778
p.E491K	ACH-000900	Lung Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	0.2778
p.E491K	NCI-H23	lung	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.2778
p.G497D	SIDM01546	Kidney Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	0.6087
p.C485R	SK-MEL-2	skin	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54278	Mismatch repair endonuclease PMS2	DEG_SCF_TRCP1_1	493:499	DSGHGST	BTRC	0.9938	More...
Q68D20	Protein PMS2CL	DEG_SCF_TRCP1_1	107:113	DSGHGST	BTRC	0.9593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHGST

Degron related mutations and impact score

Drug responses associated with PMS2 mutations

All proteins holding degron of DSGHGST