DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGHGST
Uniprot ID:
Q68D20
Source protein:
Protein PMS2CL
Source gene:
PMS2CL
Class:
DEG_SCF_TRCP1_1
Location:
107:113
E3 ligase:
BTRC
DEGRON score:
0.9593
ASA_SCORE:
62.8571
COIL:
0.7896
CONS_SCORE:
1
DSS_SCORE:
0.7103
HELIX:
0.1111
FCONS_SCORE:
1.1
RIG_SCORE:
0.5503
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PMS2CL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGHGST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P54278
Mismatch repair endonuclease PMS2
DEG_SCF_TRCP1_1
493:499
DSGHGST
BTRC
0.9938
More...
Q68D20
Protein PMS2CL
DEG_SCF_TRCP1_1
107:113
DSGHGST
BTRC
0.9593
More...