DegronMD - P17676(CEBPB)

FUNCTION: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:12048245, ECO:0000269|PubMed:18647749, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:9374525, ECO:0000303|PubMed:25451943}.; FUNCTION: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing. {ECO:0000250|UniProtKB:P28033}.; FUNCTION: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:P21272, ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:11741938}. View more >>

GO - Biological processes (BP): acute-phase response [GO:0006953]; brown fat cell differentiation [GO:0050873]; cellular response to amino acid stimulus [GO:0071230]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to organic cyclic compound [GO:0071407]; defense response to bacterium [GO:0042742]; embryonic placenta development [GO:0001892]; granuloma formation [GO:0002432]; hepatocyte proliferation [GO:0072574]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrated stress response signaling [GO:0140467]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver regeneration [GO:0097421]; mammary gland epithelial cell differentiation [GO:0060644]; mammary gland epithelial cell proliferation [GO:0033598]; memory [GO:0007613]; myeloid cell development [GO:0061515]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; ovarian follicle development [GO:0001541]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of sodium-dependent phosphate transport [GO:2000120]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; regulation of cell differentiation [GO:0045595]; regulation of dendritic cell differentiation [GO:2001198]; regulation of interleukin-6 production [GO:0032675]; regulation of odontoblast differentiation [GO:1901329]; regulation of osteoclast differentiation [GO:0045670]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription by RNA polymerase II [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; T-helper 1 cell activation [GO:0035711] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I73M	DO224768	BRCA	ICGC	FSPYLE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.2778
p.P88R	SIDM00690	Head and Neck Carcinoma	GDSC	FSPYLE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1111
p.Q86H	ACH-000911	Gastric Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1667
p.Q86H	ACH-000978	Endometrial/Uterine Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1667
p.Q86H	ACH-001516	Cervical Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	75:80	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEBPB

UniProt ID: P17676

Entrez ID: 1051

Protein name: CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEBPB in