DegronMD

Uniprot ID: P17676

Source protein: CCAAT/enhancer-binding protein beta

Source gene: CEBPB

Class: LIG_APCC_ABBA_1

Location: 75:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9992

ASA_SCORE: 65.75

COIL: 0.871

CONS_SCORE: 0.4264

DSS_SCORE: 0.6328

HELIX: 0.0678

FCONS_SCORE: 1.2152

RIG_SCORE: 0.7382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I73M	DO224768	BRCA	ICGC	FSPYLE	LIG_APCC_ABBA_1	0.2778
p.P88R	SIDM00690	Head and Neck Carcinoma	GDSC	FSPYLE	LIG_APCC_ABBA_1	0.1111
p.Q86H	ACH-000911	Gastric Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	0.1667
p.Q86H	ACH-000978	Endometrial/Uterine Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	0.1667
p.Q86H	ACH-001516	Cervical Cancer	CCLE	FSPYLE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17676	CCAAT/enhancer-binding protein beta	LIG_APCC_ABBA_1	75:80	FSPYLE	APC,CDC20,FZR1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons