DegronMD - P17677(GAP43)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K55M	TCGA-34-2609	LUSC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.K55M	DO26981	LUSC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.D53Y	TCGA-37-3792	LUSC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53Y	DO27192	LUSC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.F39L	TCGA-AP-A1DV	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation altering degron motif	0.6981
p.F39L	DO43186	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation altering degron motif	0.6981
p.D53N	TCGA-AP-A1DV	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	TCGA-EO-A22R	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	TCGA-FW-A3R5	SKCM	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	DO37406	SKCM	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	DO43186	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	DO42713	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	SIDM01680	Non-Cancerous	GDSC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.D53N	ACH-002364	Non-Cancerous	CCLE	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1944
p.K55N	TCGA-C5-A7UH	CESC	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.K55N	DO49891	CESC	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.K55N	DO228193	LICA	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.K55N	DO46542	OV	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation substituting flanking lysine	0.25
p.W43C	TCGA-E2-A14X	BRCA	TCGA	IQASFRGHITR	SCF_FBXL2	38:48	Mutation altering degron motif	0.7
p.W43C	DO3874	BRCA	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation altering degron motif	0.7
p.Q58K	DO225331	BRCA	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.0556
p.R31L	DO229041	LICA	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1389
p.K49N	DO35206	PACA	ICGC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.3056
p.Q54P	SIDM00410	Other Blood Cancers	GDSC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1667
p.Q54P	ACH-002317	Leukemia	CCLE	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1667
p.Q54P	YT	haematopoietic and lymphoid tissue	COSMIC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation rewiring degron network	0.1667
p.L37F	SIDM00677	Colorectal Carcinoma	GDSC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation blocking ubiquitination signal	0.75
p.L37F	ACH-000007	Colon/Colorectal Cancer	CCLE	IQASFRGHITR	SCF_FBXL2	38:48	Mutation blocking ubiquitination signal	0.75
p.L37F	LS-513	large intestine	COSMIC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation blocking ubiquitination signal	0.75
p.R43H	HCT-15	large intestine	COSMIC	IQASFRGHITR	SCF_FBXL2	38:48	Mutation altering degron motif	0.8244

Kaplan plot for GAP43 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAP43

UniProt ID: P17677

Entrez ID: 2596

Protein name: Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Neural phosphoprotein B-50) (pp46)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAP43 in