DegronMD

Uniprot ID: P17677

Source protein: Neuromodulin

Source gene: GAP43

Class: SCF_FBXL2

Location: 38:48

E3 ligase: FBXL2

DEGRON score: 0.9489

ASA_SCORE: 84.4727

COIL: 0.5863

CONS_SCORE: 0.998

DSS_SCORE: 0.5538

HELIX: 0.2808

FCONS_SCORE: 1.1463

RIG_SCORE: 0.728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K55M	TCGA-34-2609	LUSC	TCGA	IQASFRGHITR	SCF_FBXL2	0.25
p.K55M	DO26981	LUSC	ICGC	IQASFRGHITR	SCF_FBXL2	0.25
p.D53Y	TCGA-37-3792	LUSC	TCGA	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53Y	DO27192	LUSC	ICGC	IQASFRGHITR	SCF_FBXL2	0.1944
p.F39L	TCGA-AP-A1DV	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	0.6981
p.F39L	DO43186	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	0.6981
p.D53N	TCGA-AP-A1DV	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	TCGA-EO-A22R	UCEC	TCGA	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	TCGA-FW-A3R5	SKCM	TCGA	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	DO37406	SKCM	ICGC	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	DO43186	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	DO42713	UCEC	ICGC	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	SIDM01680	Non-Cancerous	GDSC	IQASFRGHITR	SCF_FBXL2	0.1944
p.D53N	ACH-002364	Non-Cancerous	CCLE	IQASFRGHITR	SCF_FBXL2	0.1944
p.K55N	TCGA-C5-A7UH	CESC	TCGA	IQASFRGHITR	SCF_FBXL2	0.25
p.K55N	DO49891	CESC	ICGC	IQASFRGHITR	SCF_FBXL2	0.25
p.K55N	DO228193	LICA	ICGC	IQASFRGHITR	SCF_FBXL2	0.25
p.K55N	DO46542	OV	ICGC	IQASFRGHITR	SCF_FBXL2	0.25
p.W43C	TCGA-E2-A14X	BRCA	TCGA	IQASFRGHITR	SCF_FBXL2	0.7
p.W43C	DO3874	BRCA	ICGC	IQASFRGHITR	SCF_FBXL2	0.7
p.Q58K	DO225331	BRCA	ICGC	IQASFRGHITR	SCF_FBXL2	0.0556
p.R31L	DO229041	LICA	ICGC	IQASFRGHITR	SCF_FBXL2	0.1389
p.K49N	DO35206	PACA	ICGC	IQASFRGHITR	SCF_FBXL2	0.3056
p.Q54P	SIDM00410	Other Blood Cancers	GDSC	IQASFRGHITR	SCF_FBXL2	0.1667
p.Q54P	ACH-002317	Leukemia	CCLE	IQASFRGHITR	SCF_FBXL2	0.1667
p.Q54P	YT	haematopoietic_and_lymphoid_tissue	COSMIC	IQASFRGHITR	SCF_FBXL2	0.1667
p.L37F	SIDM00677	Colorectal Carcinoma	GDSC	IQASFRGHITR	SCF_FBXL2	0.75
p.L37F	ACH-000007	Colon/Colorectal Cancer	CCLE	IQASFRGHITR	SCF_FBXL2	0.75
p.L37F	LS-513	large_intestine	COSMIC	IQASFRGHITR	SCF_FBXL2	0.75
p.R43H	HCT-15	large_intestine	COSMIC	IQASFRGHITR	SCF_FBXL2	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQASFRGHITR

Degron related mutations and impact score

Drug responses associated with GAP43 mutations

All proteins holding degron of IQASFRGHITR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17677	Neuromodulin	SCF_FBXL2	38:48	IQASFRGHITR	FBXL2	0.9489	More...