DegronMD - P18075(BMP7)

GO - Biological processes (BP): allantois development [GO:1905069]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle tissue development [GO:0048738]; cardiac septum morphogenesis [GO:0060411]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; chorio-allantoic fusion [GO:0060710]; dendrite development [GO:0016358]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; endocardial cushion formation [GO:0003272]; epithelial cell differentiation [GO:0030855]; epithelial to mesenchymal transition [GO:0001837]; heart trabecula morphogenesis [GO:0061384]; hindbrain development [GO:0030902]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell death [GO:0060548]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription, DNA-templated [GO:0045892]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural fold elevation formation [GO:0021502]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; pericardium morphogenesis [GO:0003344]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905312]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of gene expression [GO:0010628]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to nucleus [GO:0034504]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; steroid hormone mediated signaling pathway [GO:0043401]; ureteric bud development [GO:0001657] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R45H	TCGA-F4-6703	COAD	TCGA	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0556
p.R45H	DO9908	COAD	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0556
p.L46P	TCGA-UB-A7MB	LIHC	TCGA	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0833
p.L46P	DO52318	LIHC	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.0833
p.R69C	DO233760	GACA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1667
p.H71N	DO228952	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1111
p.R69S	DO229028	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1667
p.S48R	DO229041	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1389
p.M54I	DO27811	MALY	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.3056
p.G63D	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6087
p.G63N	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6284
p.G63S	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.5882
p.R69L	SIDM00189	Melanoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.1667
p.G63R	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6457
p.R52W	ACH-001538	Bile Duct Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMP7

UniProt ID: P18075

Entrez ID: 655

Protein name: Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMP7 in