DegronMD

Uniprot ID: P18075

Source protein: Bone morphogenetic protein 7

Source gene: BMP7

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5854

ASA_SCORE: 53.8667

COIL: 0.223

CONS_SCORE: 0.6488

DSS_SCORE: 0.45

HELIX: 0.7758

FCONS_SCORE: 1.3349

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R45H	TCGA-F4-6703	COAD	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R45H	DO9908	COAD	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.L46P	TCGA-UB-A7MB	LIHC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0833
p.L46P	DO52318	LIHC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0833
p.R69C	DO233760	GACA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.H71N	DO228952	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R69S	DO229028	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.S48R	DO229041	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1389
p.M54I	DO27811	MALY	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.3056
p.G63D	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.6087
p.G63N	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.6284
p.G63S	DO220891	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.5882
p.R69L	SIDM00189	Melanoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.G63R	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.6457
p.R52W	ACH-001538	Bile Duct Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons