DegronMD

Uniprot ID: P22003

Source protein: Bone morphogenetic protein 5

Source gene: BMP5

Class: DEG_APCC_DBOX_1

Location: 52:60

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6319

ASA_SCORE: 49.9667

COIL: 0.2213

CONS_SCORE: 0.6381

DSS_SCORE: 0.3508

HELIX: 0.7776

FCONS_SCORE: 1.2037

RIG_SCORE: 0.7902

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R42I	TCGA-06-5416	GBM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42I	TCGA-49-AARO	LUAD	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42I	TCGA-BS-A0UF	UCEC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42I	DO10880	GBM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42I	DO218924	LUAD	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42I	DO41488	UCEC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R49W	TCGA-32-2616	GBM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.25
p.R49W	DO13462	GBM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.25
p.R49P	TCGA-37-5819	LUSC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.25
p.R49P	DO26479	LUSC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.25
p.Q52K	TCGA-85-8353	LUSC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.5833
p.Q52K	DO20928	KIRP	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.5833
p.Q52K	DO229025	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.5833
p.Q52K	DO45530	LUSC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.5833
p.I55L	TCGA-AP-A051	UCEC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.6063
p.I55L	DO42673	UCEC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.6063
p.E47K	TCGA-AP-A1DV	UCEC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.E47K	TCGA-RP-A695	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.E47K	DO234298	ESAD	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.E47K	DO51270	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.E47K	DO43186	UCEC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.R48I	TCGA-BS-A0TC	UCEC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.2222
p.R48I	DO42400	UCEC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2222
p.E54K	TCGA-D3-A51J	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.591
p.E54K	TCGA-EE-A3J8	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.591
p.E54K	TCGA-W3-AA1Q	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.591
p.E54K	DO47276	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.591
p.E54K	DO47359	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.591
p.E54K	DO219487	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.591
p.R44Q	TCGA-D3-A8GO	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	DO233259	GACA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	DO51242	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	SIDM00795	Melanoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	ACH-000219	Skin Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	ACH-002001	Skin Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	ACH-002002	Skin Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	ACH-002003	Skin Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.R44Q	A375	skin	COSMIC	QREILSILG	DEG_APCC_DBOX_1	0.1111
p.N45D	TCGA-DU-6392	LGG	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1389
p.N45D	DO22237	LGG	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1389
p.P65H	TCGA-FF-8042	DLBC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.P65H	DO222306	DLBC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1944
p.R42K	TCGA-FW-A3R5	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R42K	DO37406	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.N45H	TCGA-HD-8635	HNSC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.1389
p.N45H	DO14574	HNSC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.1389
p.E50K	TCGA-IH-A3EA	SKCM	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.2778
p.E50K	DO50970	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2778
p.E50K	DO220899	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2778
p.E50K	DO222837	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2778
p.E50K	DO37667	SKCM	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2778
p.S57C	TCGA-PG-A914	UCEC	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.643
p.S57C	DO234262	ESAD	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.643
p.S57C	DO52421	UCEC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.643
p.S69L	TCGA-XF-A8HD	BLCA	TCGA	QREILSILG	DEG_APCC_DBOX_1	0.0833
p.S69L	DO49795	BLCA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0833
p.S69L	DO222908	MELA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0833
p.R48K	DO233269	GACA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.2222
p.I51T	DO233203	GACA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.3056
p.I51T	DO228566	LICA	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.3056
p.P70A	DO23240	LINC	ICGC	QREILSILG	DEG_APCC_DBOX_1	0.0556
p.R49L	SIDM00120	Prostate Carcinoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.25
p.R49L	ACH-000979	Prostate Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.25
p.R49L	DU-145	prostate	COSMIC	QREILSILG	DEG_APCC_DBOX_1	0.25
p.H46D	SIDM00892	Breast Carcinoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.H46D	ACH-000818	Breast Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.H46D	BT-483	breast	COSMIC	QREILSILG	DEG_APCC_DBOX_1	0.1667
p.L56F	SIDM00118	Colorectal Carcinoma	GDSC	QREILSILG	DEG_APCC_DBOX_1	0.6981
p.L56F	ACH-001081	Colon/Colorectal Cancer	CCLE	QREILSILG	DEG_APCC_DBOX_1	0.6981
p.L56F	HCC2998	large_intestine	COSMIC	QREILSILG	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18075	Bone morphogenetic protein 7	DEG_APCC_DBOX_1	55:63	QREILSILG	APC,CDC20,FZR1	0.5854	More...
P22003	Bone morphogenetic protein 5	DEG_APCC_DBOX_1	52:60	QREILSILG	APC,CDC20,FZR1	0.6319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QREILSILG

Degron related mutations and impact score

Drug responses associated with BMP5 mutations

All proteins holding degron of QREILSILG