DegronMD - P18089(ADRA2B)

ADRA2B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N247S	TCGA-60-2724	LUSC	TCGA	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.25
p.N247S	DO26540	LUSC	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.25
p.S252F	TCGA-EE-A29M	SKCM	TCGA	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation altering degron motif	0.7982
p.S252F	DO222423	MELA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation altering degron motif	0.7982
p.S252F	DO37425	SKCM	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation altering degron motif	0.7982
p.S252F	DO37404	SKCM	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation altering degron motif	0.7982
p.S252P	DO233918	GACA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation altering degron motif	0.6752
p.G248E	DO220875	MELA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.2778
p.E257K	SIDM00545	Melanoma	GDSC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.2778
p.E257K	ACH-000987	Skin Cancer	CCLE	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.2778
p.E257K	Mewo	skin	COSMIC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.2778
p.E258D	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.25
p.E258D	ACH-000553	Lung Cancer	CCLE	SKSTGE	DEG_Kelch_Keap1_1	250:255	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc