DegronMD

Uniprot ID: P18089

Source protein: Alpha-2B adrenergic receptor

Source gene: ADRA2B

Class: DEG_Kelch_Keap1_1

Location: 250:255

E3 ligase: KEAP1

DEGRON score: 0.743

ASA_SCORE: 81.0333

COIL: 0.8178

CONS_SCORE: 0.3227

DSS_SCORE: 0.7697

HELIX: 0.0657

FCONS_SCORE: 0.9784

RIG_SCORE: 0.5601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N247S	TCGA-60-2724	LUSC	TCGA	SKSTGE	DEG_Kelch_Keap1_1	0.25
p.N247S	DO26540	LUSC	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.25
p.S252F	TCGA-EE-A29M	SKCM	TCGA	SKSTGE	DEG_Kelch_Keap1_1	0.7982
p.S252F	DO222423	MELA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.7982
p.S252F	DO37425	SKCM	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.7982
p.S252F	DO37404	SKCM	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.7982
p.S252P	DO233918	GACA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.6752
p.G248E	DO220875	MELA	ICGC	SKSTGE	DEG_Kelch_Keap1_1	0.2778
p.E257K	SIDM00545	Melanoma	GDSC	SKSTGE	DEG_Kelch_Keap1_1	0.2778
p.E257K	ACH-000987	Skin Cancer	CCLE	SKSTGE	DEG_Kelch_Keap1_1	0.2778
p.E257K	Mewo	skin	COSMIC	SKSTGE	DEG_Kelch_Keap1_1	0.2778
p.E258D	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	SKSTGE	DEG_Kelch_Keap1_1	0.25
p.E258D	ACH-000553	Lung Cancer	CCLE	SKSTGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18089	Alpha-2B adrenergic receptor	DEG_Kelch_Keap1_1	250:255	SKSTGE	KEAP1	0.743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons