DegronMD - P18206(VCL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E494Q	TCGA-22-4595	LUSC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.6744
p.E494Q	DO26641	LUSC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.6744
p.E494D	TCGA-AP-A059	UCEC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.5647
p.E494D	DO41361	UCEC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.5647
p.P486L	TCGA-D3-A5GL	SKCM	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.2778
p.P486L	DO233898	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.2778
p.P486L	DO47430	SKCM	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.2778
p.P486L	SIDM02061	Esophageal Carcinoma	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.2778
p.A489V	TCGA-ES-A2HS	LIHC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.5825
p.A489V	DO22838	LIHC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.5825
p.R479Q	TCGA-F1-A72C	STAD	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.0833
p.R479Q	DO50125	STAD	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.0833
p.R502W	DO233146	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.1111
p.R502W	DO38663	STAD	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.1111
p.L493I	DO233944	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation altering degron motif	0.6063
p.G495V	DO228978	LICA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.3056
p.G495C	DO229035	LICA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.3056
p.N478S	SIDM01175	Other Sarcomas	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.0556
p.N478S	ACH-002309	Sarcoma	CCLE	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.0556
p.N478S	SW684	soft tissue	COSMIC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.0556
p.R502G	SIDM00125	Kidney Carcinoma	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.1111
p.R502G	ACH-000649	Kidney Cancer	CCLE	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.1111
p.R502G	786-0	kidney	COSMIC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	488:494	Mutation rewiring degron network	0.1111

Kaplan plot for VCL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VCL

UniProt ID: P18206

Entrez ID: 7414

Protein name: Vinculin (Metavinculin) (MV)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VCL in