DegronMD

Uniprot ID: P18206

Source protein: Vinculin

Source gene: VCL

Class: LIG_APCC_ABBAyCdc20_2

Location: 488:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8317

ASA_SCORE: 75.1714

COIL: 0.4491

CONS_SCORE: 0.4052

DSS_SCORE: 0.4613

HELIX: 0.5166

FCONS_SCORE: 1.0058

RIG_SCORE: 0.7664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E494Q	TCGA-22-4595	LUSC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E494Q	DO26641	LUSC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E494D	TCGA-AP-A059	UCEC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E494D	DO41361	UCEC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.5647
p.P486L	TCGA-D3-A5GL	SKCM	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P486L	DO233898	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P486L	DO47430	SKCM	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P486L	SIDM02061	Esophageal Carcinoma	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A489V	TCGA-ES-A2HS	LIHC	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.5825
p.A489V	DO22838	LIHC	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.5825
p.R479Q	TCGA-F1-A72C	STAD	TCGA	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R479Q	DO50125	STAD	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R502W	DO233146	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R502W	DO38663	STAD	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L493I	DO233944	GACA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.6063
p.G495V	DO228978	LICA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G495C	DO229035	LICA	ICGC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.N478S	SIDM01175	Other Sarcomas	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N478S	ACH-002309	Sarcoma	CCLE	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.N478S	SW684	soft_tissue	COSMIC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R502G	SIDM00125	Kidney Carcinoma	GDSC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R502G	ACH-000649	Kidney Cancer	CCLE	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R502G	786-0	kidney	COSMIC	KAAVHLE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18206	Vinculin	LIG_APCC_ABBAyCdc20_2	488:494	KAAVHLE	APC,CDC20,FZR1	0.8317	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons