DegronMD - P18433(PTPRA)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y271C	TCGA-BG-A0M4	UCEC	TCGA	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation blocking phosphorylation signal	0.5278
p.Y271C	DO41686	UCEC	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation blocking phosphorylation signal	0.5278
p.D294N	TCGA-HC-7819	PRAD	TCGA	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.D294N	DO49810	PRAD	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.D278Y	DO229037	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.2778
p.R270Q	DO229056	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0556
p.S280A	DO50890	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6477
p.P276L	DO45141	LIRI	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.2222
p.V282I	SIDM00983	Bladder Carcinoma	GDSC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.5965
p.V282I	647-V	urinary tract	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.5965
p.H283Y	SIDM00150	Colorectal Carcinoma	GDSC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6118
p.H283Y	KM12	large intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation altering degron motif	0.6118
p.V273I	ACH-000896	Bladder Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1389
p.V273I	647-V	urinary tract	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1389
p.H274Y	ACH-000969	Colon/Colorectal Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.H274Y	KM12	large intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.1667
p.E279K	ACH-000975	Lung Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.3056
p.K298N	ACH-000991	Colon/Colorectal Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0556
p.K298N	SNU-81	large intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	280:288	Mutation rewiring degron network	0.0556

Kaplan plot for PTPRA in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRA

UniProt ID: P18433

Entrez ID: 5786

Protein name: Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PTPRA in