DegronMD

Uniprot ID: P18433

Source protein: Receptor-type tyrosine-protein phosphatase alpha

Source gene: PTPRA

Class: DEG_APCC_DBOX_1

Location: 280:288

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8667

ASA_SCORE: 50.9222

COIL: 0.4413

CONS_SCORE: 0.6527

DSS_SCORE: 0.37

HELIX: 0.0102

FCONS_SCORE: 1.0161

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y271C	TCGA-BG-A0M4	UCEC	TCGA	SRVHLTPVE	DEG_APCC_DBOX_1	0.5278
p.Y271C	DO41686	UCEC	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.5278
p.D294N	TCGA-HC-7819	PRAD	TCGA	SRVHLTPVE	DEG_APCC_DBOX_1	0.1667
p.D294N	DO49810	PRAD	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.1667
p.D278Y	DO229037	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.2778
p.R270Q	DO229056	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.0556
p.S280A	DO50890	LICA	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.6477
p.P276L	DO45141	LIRI	ICGC	SRVHLTPVE	DEG_APCC_DBOX_1	0.2222
p.V282I	SIDM00983	Bladder Carcinoma	GDSC	SRVHLTPVE	DEG_APCC_DBOX_1	0.5965
p.V282I	647-V	urinary_tract	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	0.5965
p.H283Y	SIDM00150	Colorectal Carcinoma	GDSC	SRVHLTPVE	DEG_APCC_DBOX_1	0.6118
p.H283Y	KM12	large_intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	0.6118
p.V273I	ACH-000896	Bladder Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	0.1389
p.V273I	647-V	urinary_tract	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	0.1389
p.H274Y	ACH-000969	Colon/Colorectal Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	0.1667
p.H274Y	KM12	large_intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	0.1667
p.E279K	ACH-000975	Lung Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	0.3056
p.K298N	ACH-000991	Colon/Colorectal Cancer	CCLE	SRVHLTPVE	DEG_APCC_DBOX_1	0.0556
p.K298N	SNU-81	large_intestine	COSMIC	SRVHLTPVE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18433	Receptor-type tyrosine-protein phosphatase alpha	DEG_APCC_DBOX_1	280:288	SRVHLTPVE	APC,CDC20,FZR1	0.8667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons