DegronMD - P18850(ATF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A145V	TCGA-2W-A8YY	CESC	TCGA	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145V	DO223732	CESC	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.S97Y	TCGA-A5-A0G2	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.712
p.S97Y	DO41235	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.712
p.R106W	TCGA-AG-A002	READ	TCGA	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1389
p.S127Y	TCGA-B5-A1MR	UCEC	TCGA	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.S127Y	DO41758	UCEC	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.S143F	TCGA-FD-A62O	BLCA	TCGA	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1667
p.S143F	DO44069	BLCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1667
p.V102F	TCGA-FI-A2D5	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.25
p.V102F	DO41331	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.25
p.P131A	TCGA-OR-A5J7	ACC	TCGA	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.3056
p.A145P	DO228483	BRCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO227999	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO229013	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO229016	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO229005	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO223150	ESCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO229505	LAML	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO228941	LICA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO231212	LUSC	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.A145P	DO51521	PACA	ICGC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1111
p.D85Y	DO230343	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0556
p.L93R	DO231799	LINC	ICGC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.2778
p.R106Q	DO33091	PACA	ICGC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1389
p.D109G	SIDM00848	Ewing's Sarcoma	GDSC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0556
p.D109G	SIDM01347	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0556
p.D109G	A673	bone	COSMIC	PASSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0556
p.L142F	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.L142F	ACH-000938	Leukemia	CCLE	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944
p.L142F	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LSLYGE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1944

Kaplan plot for ATF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATF6

UniProt ID: P18850

Entrez ID: 22926

Protein name: Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATF6 in