DegronMD

Uniprot ID: P18850

Source protein: Cyclic AMP-dependent transcription factor ATF-6 alpha

Source gene: ATF6

Class: LIG_APCC_ABBA_1

Location: 132:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9334

ASA_SCORE: 77.1833

COIL: 0.7688

CONS_SCORE: 0.3848

DSS_SCORE: 0.5909

HELIX: 0.1162

FCONS_SCORE: 1.0433

RIG_SCORE: 0.6371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145V	TCGA-2W-A8YY	CESC	TCGA	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145V	DO223732	CESC	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.S127Y	TCGA-B5-A1MR	UCEC	TCGA	LSLYGE	LIG_APCC_ABBA_1	0.1944
p.S127Y	DO41758	UCEC	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1944
p.S143F	TCGA-FD-A62O	BLCA	TCGA	LSLYGE	LIG_APCC_ABBA_1	0.1667
p.S143F	DO44069	BLCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1667
p.P131A	TCGA-OR-A5J7	ACC	TCGA	LSLYGE	LIG_APCC_ABBA_1	0.3056
p.A145P	DO228483	BRCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO227999	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO229013	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO229016	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO229005	COCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO223150	ESCA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO229505	LAML	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO228941	LICA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO231212	LUSC	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.A145P	DO51521	PACA	ICGC	LSLYGE	LIG_APCC_ABBA_1	0.1111
p.L142F	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LSLYGE	LIG_APCC_ABBA_1	0.1944
p.L142F	ACH-000938	Leukemia	CCLE	LSLYGE	LIG_APCC_ABBA_1	0.1944
p.L142F	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LSLYGE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18850	Cyclic AMP-dependent transcription factor ATF-6 alpha	LIG_APCC_ABBA_1	132:137	LSLYGE	APC,CDC20,FZR1	0.9334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons