DegronMD - P19388(POLR2E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R52W	TCGA-BR-8284	STAD	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2778
p.R52W	DO38491	STAD	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2778
p.D57N	TCGA-DK-A1AC	BLCA	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.5821
p.D57N	DO514	BLCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.5821
p.P53L	TCGA-IB-7651	PAAD	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.P53L	DO46657	PAAD	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.3056
p.Q71H	DO5808	BRCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0833
p.R54W	DO230315	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.7523
p.S44F	DO229010	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.S44F	DO229013	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.S44F	DO229016	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.S44F	DO229003	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.S44F	DO229005	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.0556
p.R52Q	DO233881	GACA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.2778
p.D46E	DO229037	LICA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1111
p.D67E	DO232073	ORCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1944
p.D70Y	DO232924	PEME	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1111
p.P48L	SIDM00945	Colorectal Carcinoma	GDSC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1667
p.P48L	ACH-000895	Colon/Colorectal Cancer	CCLE	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1667
p.P48L	CL-34	large intestine	COSMIC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation rewiring degron network	0.1667
p.V60M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRTDLTVLV	DEG_APCC_DBOX_1	54:62	Mutation altering degron motif	0.6097

Kaplan plot for POLR2E in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLR2E

UniProt ID: P19388

Entrez ID: 5434

Protein name: DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLR2E in