DegronMD

Uniprot ID: P19388

Source protein: DNA-directed RNA polymerases I, II, and III subunit RPABC1

Source gene: POLR2E

Class: DEG_APCC_DBOX_1

Location: 54:62

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9667

ASA_SCORE: 54.5

COIL: 0.5367

CONS_SCORE: 0.5289

DSS_SCORE: 0.5911

HELIX: 0.0658

FCONS_SCORE: 1.1874

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R52W	TCGA-BR-8284	STAD	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	0.2778
p.R52W	DO38491	STAD	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.2778
p.D57N	TCGA-DK-A1AC	BLCA	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	0.5821
p.D57N	DO514	BLCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.5821
p.P53L	TCGA-IB-7651	PAAD	TCGA	RRTDLTVLV	DEG_APCC_DBOX_1	0.3056
p.P53L	DO46657	PAAD	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.3056
p.Q71H	DO5808	BRCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0833
p.R54W	DO230315	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.7523
p.S44F	DO229010	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0556
p.S44F	DO229013	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0556
p.S44F	DO229016	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0556
p.S44F	DO229003	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0556
p.S44F	DO229005	COCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.0556
p.R52Q	DO233881	GACA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.2778
p.D46E	DO229037	LICA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.1111
p.D67E	DO232073	ORCA	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.1944
p.D70Y	DO232924	PEME	ICGC	RRTDLTVLV	DEG_APCC_DBOX_1	0.1111
p.P48L	SIDM00945	Colorectal Carcinoma	GDSC	RRTDLTVLV	DEG_APCC_DBOX_1	0.1667
p.P48L	ACH-000895	Colon/Colorectal Cancer	CCLE	RRTDLTVLV	DEG_APCC_DBOX_1	0.1667
p.P48L	CL-34	large_intestine	COSMIC	RRTDLTVLV	DEG_APCC_DBOX_1	0.1667
p.V60M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RRTDLTVLV	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19388	DNA-directed RNA polymerases I, II, and III subunit RPABC1	DEG_APCC_DBOX_1	54:62	RRTDLTVLV	APC,CDC20,FZR1	0.9667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons