DegronMD - P19404(NDUFV2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P52Q	TCGA-BF-A1PU	SKCM	TCGA	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.P52Q	DO50278	SKCM	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.N32S	TCGA-DD-AADC	LIHC	TCGA	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1667
p.N32S	DO52230	LIHC	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1667
p.D43Y	TCGA-EO-A22R	UCEC	TCGA	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.7325
p.D43Y	DO42713	UCEC	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.7325
p.V29A	DO229010	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V29A	DO229013	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V29A	DO229016	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V29A	DO229003	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V29A	DO225404	LAML	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V29F	DO229022	LICA	ICGC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.V40M	SIDM01090	Colorectal Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097
p.V40M	SIDM00690	Head and Neck Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097
p.V40M	SIDM00694	Other Solid Cancers	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6097
p.F39C	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.F39C	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.F39C	ACH-000843	Lung Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.F39C	ACH-002058	Leukemia	CCLE	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.F39C	HARA	lung	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.F39C	ATN-1	haematopoietic and lymphoid tissue	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5996
p.N48S	SIDM00878	Breast Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.N48S	ACH-000930	Breast Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.N48S	HCC1569	breast	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.E46K	SIDM00248	Gastric Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.E46K	ACH-000758	Gastric Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.N51S	HCC1569	breast	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation blocking phosphorylation signal	0.5556
p.F42C	ATN-1	haematopoietic and lymphoid tissue	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.7108
p.F42C	HARA	lung	COSMIC	LFVHRD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.7108

Kaplan plot for NDUFV2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDUFV2

UniProt ID: P19404

Entrez ID: 4729

Protein name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDUFV2 in