DegronMD

Uniprot ID: P19404

Source protein: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Source gene: NDUFV2

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9523

ASA_SCORE: 66.6833

COIL: 0.5885

CONS_SCORE: 0.3627

DSS_SCORE: 0.5779

HELIX: 0.0975

FCONS_SCORE: 1.2076

RIG_SCORE: 0.753

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P52Q	TCGA-BF-A1PU	SKCM	TCGA	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.P52Q	DO50278	SKCM	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.N32S	TCGA-DD-AADC	LIHC	TCGA	LFVHRD	LIG_APCC_ABBA_1	0.1667
p.N32S	DO52230	LIHC	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.1667
p.D43Y	TCGA-EO-A22R	UCEC	TCGA	LFVHRD	LIG_APCC_ABBA_1	0.7325
p.D43Y	DO42713	UCEC	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.7325
p.V29A	DO229010	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V29A	DO229013	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V29A	DO229016	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V29A	DO229003	COCA	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V29A	DO225404	LAML	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V29F	DO229022	LICA	ICGC	LFVHRD	LIG_APCC_ABBA_1	0.0833
p.V40M	SIDM01090	Colorectal Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.6097
p.V40M	SIDM00690	Head and Neck Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.6097
p.V40M	SIDM00694	Other Solid Cancers	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.6097
p.F39C	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.F39C	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.F39C	ACH-000843	Lung Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.F39C	ACH-002058	Leukemia	CCLE	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.F39C	HARA	lung	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.F39C	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.5996
p.N48S	SIDM00878	Breast Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.1944
p.N48S	ACH-000930	Breast Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	0.1944
p.N48S	HCC1569	breast	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.1944
p.E46K	SIDM00248	Gastric Carcinoma	GDSC	LFVHRD	LIG_APCC_ABBA_1	0.25
p.E46K	ACH-000758	Gastric Cancer	CCLE	LFVHRD	LIG_APCC_ABBA_1	0.25
p.N51S	HCC1569	breast	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.5556
p.F42C	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.7108
p.F42C	HARA	lung	COSMIC	LFVHRD	LIG_APCC_ABBA_1	0.7108

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFVHRD

Degron related mutations and impact score

Drug responses associated with NDUFV2 mutations

All proteins holding degron of LFVHRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19404	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	LIG_APCC_ABBA_1	38:43	LFVHRD	APC,CDC20,FZR1	0.9523	More...