DegronMD - P19634(SLC9A1)

GO - Biological processes (BP): cardiac muscle cell contraction [GO:0086003]; cardiac muscle cell differentiation [GO:0055007]; cell migration [GO:0016477]; cellular response to acidic pH [GO:0071468]; cellular response to antibiotic [GO:0071236]; cellular response to cold [GO:0070417]; cellular response to electrical stimulus [GO:0071257]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular sodium ion homeostasis [GO:0006883]; ion transport [GO:0006811]; maintenance of cell polarity [GO:0030011]; negative regulation of apoptotic process [GO:0043066]; neuron death [GO:0070997]; positive regulation of action potential [GO:0045760]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of calcium:sodium antiporter activity [GO:1903281]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription by RNA polymerase II [GO:0045944]; potassium ion transmembrane transport [GO:0071805]; protein complex oligomerization [GO:0051259]; proton transmembrane transport [GO:1902600]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of focal adhesion assembly [GO:0051893]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; regulation of sensory perception of pain [GO:0051930]; regulation of stress fiber assembly [GO:0051492]; regulation of the force of heart contraction by cardiac conduction [GO:0086092]; response to acidic pH [GO:0010447]; response to muscle stretch [GO:0035994]; sodium ion export across plasma membrane [GO:0036376]; sodium ion import across plasma membrane [GO:0098719] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A781V	TCGA-AA-3950	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation altering degron motif	0.5825
p.A781V	TCGA-BI-A0VS	CESC	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation altering degron motif	0.5825
p.A781T	TCGA-CM-6674	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation altering degron motif	0.6028
p.A781T	TCGA-G4-6309	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation altering degron motif	0.6028
p.S787I	TCGA-HF-7132	STAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation blocking phosphorylation signal	0.6667
p.S770L	TCGA-XK-AAIW	PRAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation blocking phosphorylation signal	0.5833
p.T769N	SIDM01782	Oral Cavity Carcinoma	GDSC	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation rewiring degron network	0.1111
p.T769N	ACH-000723	Head and Neck Cancer	CCLE	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation rewiring degron network	0.1111
p.S771P	ACH-001393	Breast Cancer	CCLE	VFTPAPS	DEG_SCF_FBW7_1	777:783	Mutation blocking phosphorylation signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A1

UniProt ID: P19634

Entrez ID: 6548

Protein name: Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A1 in