DegronMD

Uniprot ID: P19634

Source protein: Sodium/hydrogen exchanger 1

Source gene: SLC9A1

Class: DEG_SCF_FBW7_1

Location: 777:783

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 82.9286

COIL: 0.9297

CONS_SCORE: 0.339

DSS_SCORE: 0.8478

HELIX: 0.0276

FCONS_SCORE: 1.0375

RIG_SCORE: 0.6132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A781V	TCGA-AA-3950	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.5825
p.A781V	TCGA-BI-A0VS	CESC	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.5825
p.A781T	TCGA-CM-6674	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.6028
p.A781T	TCGA-G4-6309	COAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.6028
p.S787I	TCGA-HF-7132	STAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.6667
p.S770L	TCGA-XK-AAIW	PRAD	TCGA	VFTPAPS	DEG_SCF_FBW7_1	0.5833
p.T769N	SIDM01782	Oral Cavity Carcinoma	GDSC	VFTPAPS	DEG_SCF_FBW7_1	0.1111
p.T769N	ACH-000723	Head and Neck Cancer	CCLE	VFTPAPS	DEG_SCF_FBW7_1	0.1111
p.S771P	ACH-001393	Breast Cancer	CCLE	VFTPAPS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19634	Sodium/hydrogen exchanger 1	DEG_SCF_FBW7_1	777:783	VFTPAPS	FBXW7	0.9899	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons