DegronMD - P20020(ATP2B1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I1194V	TCGA-29-1695	OV	TCGA	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.5965
p.G1193E	TCGA-W3-AA1V	SKCM	TCGA	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.7199
p.T1197K	SIDM00244	Neuroblastoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.8417
p.T1197K	ACH-002083	Neuroblastoma	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.8417
p.T1197K	NB69	autonomic ganglia	COSMIC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.8417
p.P1181H	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation rewiring degron network	0.0556
p.P1181H	SIDM01680	Non-Cancerous	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation rewiring degron network	0.0556
p.N1184I	SIDM00927	Small Cell Lung Carcinoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation rewiring degron network	0.1389
p.N1184I	ACH-000871	Lung Cancer	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation rewiring degron network	0.1389
p.N1184I	NCI-H510A	lung	COSMIC	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation rewiring degron network	0.1389
p.S1215G	SIDM00839	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1204:1208	Mutation blocking phosphorylation signal	0.5833
p.S1215G	ACH-000950	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1204:1208	Mutation blocking phosphorylation signal	0.5833
p.S1215G	LoVo	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1204:1208	Mutation blocking phosphorylation signal	0.5833
p.L1196F	ACH-001804	Liposarcoma	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	1191:1197	Mutation altering degron motif	0.587

Kaplan plot for ATP2B1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATP2B1

UniProt ID: P20020

Entrez ID: 490

Protein name: Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATP2B1 in