DegronMD

Uniprot ID: P20020

Source protein: Plasma membrane calcium-transporting ATPase 1

Source gene: ATP2B1

Class: DEG_SCF_TRCP1_1

Location: 1191:1197

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 74.2714

COIL: 0.7847

CONS_SCORE: 0.2065

DSS_SCORE: 0.6206

HELIX: 0.0891

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1194V	TCGA-29-1695	OV	TCGA	DSGIHLT	DEG_SCF_TRCP1_1	0.5965
p.G1193E	TCGA-W3-AA1V	SKCM	TCGA	DSGIHLT	DEG_SCF_TRCP1_1	0.7199
p.T1197K	SIDM00244	Neuroblastoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	0.8417
p.T1197K	ACH-002083	Neuroblastoma	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	0.8417
p.T1197K	NB69	autonomic_ganglia	COSMIC	DSGIHLT	DEG_SCF_TRCP1_1	0.8417
p.P1181H	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	0.0556
p.P1181H	SIDM01680	Non-Cancerous	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	0.0556
p.N1184I	SIDM00927	Small Cell Lung Carcinoma	GDSC	DSGIHLT	DEG_SCF_TRCP1_1	0.1389
p.N1184I	ACH-000871	Lung Cancer	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	0.1389
p.N1184I	NCI-H510A	lung	COSMIC	DSGIHLT	DEG_SCF_TRCP1_1	0.1389
p.L1196F	ACH-001804	Liposarcoma	CCLE	DSGIHLT	DEG_SCF_TRCP1_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20020	Plasma membrane calcium-transporting ATPase 1	DEG_SCF_TRCP1_1	1191:1197	DSGIHLT	BTRC	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons