FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine pro...
FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin. {ECO:0000250|UniProtKB:Q8BMY7, ECO:0000269|PubMed:19422058, ECO:0000269|PubMed:28554943}.
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GO - Biological processes (BP):
acrosome assembly [GO:0001675]; negative regulation of serine-type endopeptidase activity [GO:1900004]; spermatid development [GO:0007286]...
acrosome assembly [GO:0001675]; negative regulation of serine-type endopeptidase activity [GO:1900004]; spermatid development [GO:0007286]
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GO - Molecular function (MF):
endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]...
endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]
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GO - Cellular component (CC):
acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]...
acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]
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