DegronMD

Uniprot ID: P20155

Source protein: Serine protease inhibitor Kazal-type 2

Source gene: SPINK2

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6555

ASA_SCORE: 63.7778

COIL: 0.2064

CONS_SCORE: 0.5623

DSS_SCORE: 0.0009

HELIX: 0.5936

FCONS_SCORE: 1.5926

RIG_SCORE: 0.9958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L21M	TCGA-BH-A18G	BRCA	TCGA	LRLALLLLA	DEG_APCC_DBOX_1	0.1389
p.S20C	TCGA-P3-A6T4	HNSC	TCGA	LRLALLLLA	DEG_APCC_DBOX_1	0.1667
p.S23R	DO229009	LICA	ICGC	LRLALLLLA	DEG_APCC_DBOX_1	0.0833
p.T16S	DO50932	LICA	ICGC	LRLALLLLA	DEG_APCC_DBOX_1	0.2778
p.L11P	DO229259	THCA	ICGC	LRLALLLLA	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20155	Serine protease inhibitor Kazal-type 2	DEG_APCC_DBOX_1	6:14	LRLALLLLA	APC,CDC20,FZR1	0.6555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons