DegronMD - P20226(TBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P142H	TCGA-28-5211	GBM	TCGA	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0833
p.P142H	DO11016	GBM	ICGC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0833
p.S156L	TCGA-A5-A2K5	UCEC	TCGA	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation altering degron motif	0.6556
p.S156L	DO41379	UCEC	ICGC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation altering degron motif	0.6556
p.P163Q	TCGA-D3-A1QA	SKCM	TCGA	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.1667
p.P163Q	DO47469	SKCM	ICGC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.1667
p.S141F	TCGA-D3-A2J9	SKCM	TCGA	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0556
p.S141F	DO38141	SKCM	ICGC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0556
p.I161T	TCGA-DI-A1BU	UCEC	TCGA	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.2222
p.I161T	DO42023	UCEC	ICGC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.2222
p.P151A	SIDM00697	Small Cell Lung Carcinoma	GDSC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation altering degron motif	0.7503
p.P151A	ACH-000830	Lung Cancer	CCLE	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation altering degron motif	0.7503
p.P151A	NCI-H1436	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation altering degron motif	0.7503
p.V162L	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.1944
p.V162L	ACH-000510	Lung Cancer	CCLE	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.1944
p.V162L	NCI-H1299	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.1944
p.R166C	M14	skin	COSMIC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0833
p.G166V	SNU-1040	large intestine	COSMIC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0833
p.V142L	NCI-H1299	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	151:157	Mutation rewiring degron network	0.0833

Kaplan plot for TBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBP

UniProt ID: P20226

Entrez ID: 6908

Protein name: TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBP in