DegronMD

Uniprot ID: P20226

Source protein: TATA-box-binding protein

Source gene: TBP

Class: DEG_SCF_FBW7_2

Location: 151:157

E3 ligase: FBXW7

DEGRON score: 0.9402

ASA_SCORE: 79.6714

COIL: 0.8446

CONS_SCORE: 0.4221

DSS_SCORE: 0.5393

HELIX: 0.1141

FCONS_SCORE: 0.9492

RIG_SCORE: 0.6749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P142H	TCGA-28-5211	GBM	TCGA	PATPASE	DEG_SCF_FBW7_2	0.0833
p.P142H	DO11016	GBM	ICGC	PATPASE	DEG_SCF_FBW7_2	0.0833
p.S156L	TCGA-A5-A2K5	UCEC	TCGA	PATPASE	DEG_SCF_FBW7_2	0.6556
p.S156L	DO41379	UCEC	ICGC	PATPASE	DEG_SCF_FBW7_2	0.6556
p.P163Q	TCGA-D3-A1QA	SKCM	TCGA	PATPASE	DEG_SCF_FBW7_2	0.1667
p.P163Q	DO47469	SKCM	ICGC	PATPASE	DEG_SCF_FBW7_2	0.1667
p.S141F	TCGA-D3-A2J9	SKCM	TCGA	PATPASE	DEG_SCF_FBW7_2	0.0556
p.S141F	DO38141	SKCM	ICGC	PATPASE	DEG_SCF_FBW7_2	0.0556
p.I161T	TCGA-DI-A1BU	UCEC	TCGA	PATPASE	DEG_SCF_FBW7_2	0.2222
p.I161T	DO42023	UCEC	ICGC	PATPASE	DEG_SCF_FBW7_2	0.2222
p.P151A	SIDM00697	Small Cell Lung Carcinoma	GDSC	PATPASE	DEG_SCF_FBW7_2	0.7503
p.P151A	ACH-000830	Lung Cancer	CCLE	PATPASE	DEG_SCF_FBW7_2	0.7503
p.P151A	NCI-H1436	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	0.7503
p.V162L	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PATPASE	DEG_SCF_FBW7_2	0.1944
p.V162L	ACH-000510	Lung Cancer	CCLE	PATPASE	DEG_SCF_FBW7_2	0.1944
p.V162L	NCI-H1299	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	0.1944
p.R166C	M14	skin	COSMIC	PATPASE	DEG_SCF_FBW7_2	0.0833
p.G166V	SNU-1040	large_intestine	COSMIC	PATPASE	DEG_SCF_FBW7_2	0.0833
p.V142L	NCI-H1299	lung	COSMIC	PATPASE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20226	TATA-box-binding protein	DEG_SCF_FBW7_2	151:157	PATPASE	FBXW7	0.9402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons