DegronMD - P20273(CD22)

CD22

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P242T	TCGA-05-4398	LUAD	TCGA	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.7031
p.P242T	DO25847	LUAD	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.7031
p.I246T	TCGA-36-2534	OV	TCGA	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.3056
p.I246T	DO29046	OV	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.3056
p.H240Y	TCGA-AP-A051	UCEC	TCGA	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.6118
p.H240Y	DO42673	UCEC	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.6118
p.P242L	TCGA-L5-A43J	ESCA	TCGA	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.7582
p.P242L	CP66-MEL	skin	COSMIC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.7582
p.A253S	DO229037	LICA	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.1111
p.P241H	DO37407	SKCM	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation altering degron motif	0.7694
p.P252S	DO43041	UCEC	ICGC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.1389
p.P254L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.0833
p.P254L	A172	central nervous system	COSMIC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.0833
p.P247L	CP66-MEL	skin	COSMIC	VKHTPKLE	DEG_SCF_FBW7_2	238:245	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc