DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VKHTPKLE
Uniprot ID:
P20273
Source protein:
B-cell receptor CD22
Source gene:
CD22
Class:
DEG_SCF_FBW7_2
Location:
238:245
E3 ligase:
FBXW7
DEGRON score:
0.7296
ASA_SCORE:
74.75
COIL:
0.569
CONS_SCORE:
0.5385
DSS_SCORE:
0.3371
HELIX:
0.0056
FCONS_SCORE:
1.2107
RIG_SCORE:
0.8037
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P242T
TCGA-05-4398
LUAD
TCGA
VKHTPKLE
DEG_SCF_FBW7_2
0.7031
p.P242T
DO25847
LUAD
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.7031
p.I246T
TCGA-36-2534
OV
TCGA
VKHTPKLE
DEG_SCF_FBW7_2
0.3056
p.I246T
DO29046
OV
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.3056
p.H240Y
TCGA-AP-A051
UCEC
TCGA
VKHTPKLE
DEG_SCF_FBW7_2
0.6118
p.H240Y
DO42673
UCEC
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.6118
p.P242L
TCGA-L5-A43J
ESCA
TCGA
VKHTPKLE
DEG_SCF_FBW7_2
0.7582
p.P242L
CP66-MEL
skin
COSMIC
VKHTPKLE
DEG_SCF_FBW7_2
0.7582
p.A253S
DO229037
LICA
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.1111
p.P241H
DO37407
SKCM
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.7694
p.P252S
DO43041
UCEC
ICGC
VKHTPKLE
DEG_SCF_FBW7_2
0.1389
p.P254L
Jurkat
haematopoietic_and_lymphoid_tissue
COSMIC
VKHTPKLE
DEG_SCF_FBW7_2
0.0833
p.P254L
A172
central_nervous_system
COSMIC
VKHTPKLE
DEG_SCF_FBW7_2
0.0833
p.P247L
CP66-MEL
skin
COSMIC
VKHTPKLE
DEG_SCF_FBW7_2
0.2778
Drug responses associated with CD22 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKHTPKLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20273
B-cell receptor CD22
DEG_SCF_FBW7_2
238:245
VKHTPKLE
FBXW7
0.7296
More...