DegronMD - P20702(ITGAX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S652P	TCGA-BR-8680	STAD	TCGA	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.2778
p.S652P	DO47769	STAD	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.2778
p.G667W	TCGA-EB-A299	SKCM	TCGA	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.1111
p.G667W	DO37794	SKCM	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.1111
p.V650A	TCGA-N7-A4Y0	UCS	TCGA	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.2222
p.N664S	DO234230	ESAD	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.1944
p.C655F	DO229026	LICA	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation altering degron motif	0.5996
p.Q651H	DO231165	LUSC	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.25
p.C655Y	DO232761	PBCA	ICGC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation altering degron motif	0.5976
p.S668I	SIDM01129	Small Cell Lung Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation blocking phosphorylation signal	0.5278
p.S668I	ACH-000816	Lung Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation blocking phosphorylation signal	0.5278
p.S668I	NCI-H524	lung	COSMIC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation blocking phosphorylation signal	0.5278
p.R661H	SIDM00585	Hepatocellular Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.2778
p.R661H	SIDM00564	Ovarian Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.2778
p.L656R	ACH-000941	Endometrial/Uterine Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation altering degron motif	0.8428
p.T648I	ACH-001057	Lymphoma	CCLE	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation rewiring degron network	0.1667
p.Y657C	ACH-001610	Brain Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	654:659	Mutation altering degron motif	0.7087

Kaplan plot for ITGAX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGAX

UniProt ID: P20702

Entrez ID: 3687

Protein name: Integrin alpha-X (CD11 antigen-like family member C) (Leu M5) (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD antigen CD11c)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGAX in