DegronMD

Uniprot ID: P20702

Source protein: Integrin alpha-X

Source gene: ITGAX

Class: LIG_APCC_ABBA_1

Location: 654:659

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7077

ASA_SCORE: 19.5167

COIL: 0.0617

CONS_SCORE: 0.4311

DSS_SCORE: 0.0985

HELIX: 0.0065

FCONS_SCORE: 1.295

RIG_SCORE: 0.9358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S652P	TCGA-BR-8680	STAD	TCGA	ICLYID	LIG_APCC_ABBA_1	0.2778
p.S652P	DO47769	STAD	ICGC	ICLYID	LIG_APCC_ABBA_1	0.2778
p.G667W	TCGA-EB-A299	SKCM	TCGA	ICLYID	LIG_APCC_ABBA_1	0.1111
p.G667W	DO37794	SKCM	ICGC	ICLYID	LIG_APCC_ABBA_1	0.1111
p.V650A	TCGA-N7-A4Y0	UCS	TCGA	ICLYID	LIG_APCC_ABBA_1	0.2222
p.N664S	DO234230	ESAD	ICGC	ICLYID	LIG_APCC_ABBA_1	0.1944
p.C655F	DO229026	LICA	ICGC	ICLYID	LIG_APCC_ABBA_1	0.5996
p.Q651H	DO231165	LUSC	ICGC	ICLYID	LIG_APCC_ABBA_1	0.25
p.C655Y	DO232761	PBCA	ICGC	ICLYID	LIG_APCC_ABBA_1	0.5976
p.S668I	SIDM01129	Small Cell Lung Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	0.5278
p.S668I	ACH-000816	Lung Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	0.5278
p.S668I	NCI-H524	lung	COSMIC	ICLYID	LIG_APCC_ABBA_1	0.5278
p.R661H	SIDM00585	Hepatocellular Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	0.2778
p.R661H	SIDM00564	Ovarian Carcinoma	GDSC	ICLYID	LIG_APCC_ABBA_1	0.2778
p.L656R	ACH-000941	Endometrial/Uterine Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	0.8428
p.T648I	ACH-001057	Lymphoma	CCLE	ICLYID	LIG_APCC_ABBA_1	0.1667
p.Y657C	ACH-001610	Brain Cancer	CCLE	ICLYID	LIG_APCC_ABBA_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20702	Integrin alpha-X	LIG_APCC_ABBA_1	654:659	ICLYID	APC,CDC20,FZR1	0.7077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons