DegronMD - P20851(C4BPB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S162I	TCGA-23-1117	OV	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.Q177K	TCGA-B1-A47M	KIRP	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.C165R	TCGA-BR-6566	STAD	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.G173V	TCGA-CF-A47X	BLCA	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6421
p.E176D	TCGA-DK-AA6T	BLCA	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.V174M	TCGA-FI-A2D5	UCEC	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6097
p.E175D	DO51872	BLCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6758
p.G172V	DO44042	BLCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7532
p.S175G	DO224616	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO229010	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO229013	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO229016	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO229003	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO229005	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.S175G	DO234285	ESAD	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6993
p.Q176K	DO49736	KIRP	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.S161I	DO229041	LICA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1667
p.S161I	DO30830	OV	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1667
p.D166N	DO220905	MELA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.P171S	DO222727	MELA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6752
p.E165K	DO229456	SKCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.C164R	DO38217	STAD	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.V173M	DO41331	UCEC	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7208
p.S159T	SIDM00985	Burkitt's Lymphoma	GDSC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1111
p.S159T	ACH-000245	Lymphoma	CCLE	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1111
p.S159T	BL-41	haematopoietic and lymphoid tissue	COSMIC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1111
p.S158T	BL-41	haematopoietic and lymphoid tissue	COSMIC	DRYYLVGVQ	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0833

Kaplan plot for C4BPB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C4BPB

UniProt ID: P20851

Entrez ID: 725

Protein name: C4b-binding protein beta chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C4BPB in