DegronMD

Uniprot ID: P20851

Source protein: C4b-binding protein beta chain

Source gene: C4BPB

Class: DEG_APCC_DBOX_1

Location: 167:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6876

ASA_SCORE: 80.7111

COIL: 0.6126

CONS_SCORE: 0.7132

DSS_SCORE: 0.0565

HELIX: 0.0078

FCONS_SCORE: 0.9676

RIG_SCORE: 0.9478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162I	TCGA-23-1117	OV	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1944
p.Q177K	TCGA-B1-A47M	KIRP	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.2778
p.C165R	TCGA-BR-6566	STAD	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.2778
p.G173V	TCGA-CF-A47X	BLCA	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6421
p.E176D	TCGA-DK-AA6T	BLCA	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.3056
p.V174M	TCGA-FI-A2D5	UCEC	TCGA	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6097
p.E175D	DO51872	BLCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6758
p.G172V	DO44042	BLCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.7532
p.S175G	DO224616	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO229010	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO229013	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO229016	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO229003	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO229005	COCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.S175G	DO234285	ESAD	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6993
p.Q176K	DO49736	KIRP	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.3056
p.S161I	DO229041	LICA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1667
p.S161I	DO30830	OV	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1667
p.D166N	DO220905	MELA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.3056
p.P171S	DO222727	MELA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.6752
p.E165K	DO229456	SKCA	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.2778
p.C164R	DO38217	STAD	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.25
p.V173M	DO41331	UCEC	ICGC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.7208
p.S159T	SIDM00985	Burkitt's Lymphoma	GDSC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1111
p.S159T	ACH-000245	Lymphoma	CCLE	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1111
p.S159T	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.1111
p.S158T	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	DRYYLVGVQ	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20851	C4b-binding protein beta chain	DEG_APCC_DBOX_1	167:175	DRYYLVGVQ	APC,CDC20,FZR1	0.6876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DRYYLVGVQ

Degron related mutations and impact score

Drug responses associated with C4BPB mutations

All proteins holding degron of DRYYLVGVQ