DegronMD - P20933(AGA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P193H	TCGA-A5-A0GH	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6583
p.P193H	DO43634	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.6583
p.R202C	TCGA-AP-A059	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.R202C	TCGA-D3-A1QA	SKCM	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.R202C	TCGA-IB-7651	PAAD	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.R202C	DO46657	PAAD	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.R202C	DO47469	SKCM	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.R202C	DO41361	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.P184S	TCGA-B5-A3FC	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.P184S	TCGA-FW-A3R5	SKCM	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.P184S	DO37406	SKCM	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.P184S	DO41871	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.D201N	TCGA-E7-A7DU	BLCA	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.D201N	DO219016	BLCA	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.2222
p.I187V	TCGA-PK-A5HB	ACC	TCGA	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1944
p.D205E	DO229022	LICA	ICGC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.1111
p.I194S	SIDM00600	Thyroid Gland Carcinoma	GDSC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.7341
p.I194S	ACH-001528	Thyroid Cancer	CCLE	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.7341
p.I194S	IHH-4	thyroid	COSMIC	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation altering degron motif	0.7341
p.D200N	ACH-002069	Bone Cancer	CCLE	IPIHKE	LIG_APCC_ABBA_1	192:197	Mutation rewiring degron network	0.25

Kaplan plot for AGA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AGA

UniProt ID: P20933

Entrez ID: 175

Protein name: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AGA in