DegronMD

Uniprot ID: P20933

Source protein: N

Source gene: AGA

Class: LIG_APCC_ABBA_1

Location: 192:197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9272

ASA_SCORE: 82.9333

COIL: 0.7952

CONS_SCORE: 0.4033

DSS_SCORE: 0.5803

HELIX: 0.1272

FCONS_SCORE: 0.6349

RIG_SCORE: 0.7655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P193H	TCGA-A5-A0GH	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.6583
p.P193H	DO43634	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.6583
p.R202C	TCGA-AP-A059	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.R202C	TCGA-D3-A1QA	SKCM	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.R202C	TCGA-IB-7651	PAAD	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.R202C	DO46657	PAAD	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.R202C	DO47469	SKCM	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.R202C	DO41361	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.P184S	TCGA-B5-A3FC	UCEC	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1111
p.P184S	TCGA-FW-A3R5	SKCM	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1111
p.P184S	DO37406	SKCM	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1111
p.P184S	DO41871	UCEC	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1111
p.D201N	TCGA-E7-A7DU	BLCA	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.2222
p.D201N	DO219016	BLCA	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.2222
p.I187V	TCGA-PK-A5HB	ACC	TCGA	IPIHKE	LIG_APCC_ABBA_1	0.1944
p.D205E	DO229022	LICA	ICGC	IPIHKE	LIG_APCC_ABBA_1	0.1111
p.I194S	SIDM00600	Thyroid Gland Carcinoma	GDSC	IPIHKE	LIG_APCC_ABBA_1	0.7341
p.I194S	ACH-001528	Thyroid Cancer	CCLE	IPIHKE	LIG_APCC_ABBA_1	0.7341
p.I194S	IHH-4	thyroid	COSMIC	IPIHKE	LIG_APCC_ABBA_1	0.7341
p.D200N	ACH-002069	Bone Cancer	CCLE	IPIHKE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20933	N	LIG_APCC_ABBA_1	192:197	IPIHKE	APC,CDC20,FZR1	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons