DegronMD - P22570(FDXR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285W	TCGA-AJ-A3EK	UCEC	TCGA	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1944
p.Q289H	TCGA-DF-A2KU	UCEC	TCGA	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.0833
p.A281T	DO228915	LICA	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.3056
p.R281L	DO27652	LUSC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.3056
p.R281L	DO27572	LUSC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.3056
p.Q277H	DO223286	UCEC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7582
p.R273W	DO41584	UCEC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.8634
p.A277T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.7139
p.L286V	CCK-81	large intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1667
p.K267N	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation substituting flanking lysine	0.3056
p.L280V	CCK-81	large intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.5654
p.G280A	KYSE-50	oesophagus	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.754
p.K273N	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.6918
p.L266W	H-EMC-SS	bone	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation rewiring degron network	0.1667
p.L272V	CCK-81	large intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	272:280	Mutation altering degron motif	0.6765

Kaplan plot for FDXR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FDXR

UniProt ID: P22570

Entrez ID: 2232

Protein name: NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FDXR in