DegronMD

Uniprot ID: P22570

Source protein: NADPH:adrenodoxin oxidoreductase, mitochondrial

Source gene: FDXR

Class: DEG_APCC_DBOX_1

Location: 272:280

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8197

ASA_SCORE: 59.5556

COIL: 0.0822

CONS_SCORE: 0.3697

DSS_SCORE: 0.4581

HELIX: 0.9141

FCONS_SCORE: 1.4676

RIG_SCORE: 0.7987

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R285W	TCGA-AJ-A3EK	UCEC	TCGA	PRKRLTELL	DEG_APCC_DBOX_1	0.1944
p.Q289H	TCGA-DF-A2KU	UCEC	TCGA	PRKRLTELL	DEG_APCC_DBOX_1	0.0833
p.A281T	DO228915	LICA	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	0.3056
p.R281L	DO27652	LUSC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	0.3056
p.R281L	DO27572	LUSC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	0.3056
p.Q277H	DO223286	UCEC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	0.7582
p.R273W	DO41584	UCEC	ICGC	PRKRLTELL	DEG_APCC_DBOX_1	0.8634
p.A277T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRKRLTELL	DEG_APCC_DBOX_1	0.7139
p.L286V	CCK-81	large_intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.1667
p.K267N	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.3056
p.L280V	CCK-81	large_intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.5654
p.G280A	KYSE-50	oesophagus	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.754
p.K273N	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.6918
p.L266W	H-EMC-SS	bone	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.1667
p.L272V	CCK-81	large_intestine	COSMIC	PRKRLTELL	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22570	NADPH:adrenodoxin oxidoreductase, mitochondrial	DEG_APCC_DBOX_1	272:280	PRKRLTELL	APC,CDC20,FZR1	0.8197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons