CCNO
UniProt ID: P22674
Entrez ID: 10309
Protein name: Cyclin-O
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|P...
FUNCTION: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}.
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GO - Biological processes (BP):
cell division [GO:0051301]; cilium assembly [GO:0060271]; mitotic cell cycle [GO:0000278]; mitotic cell cycle phase transition [GO:0044772]; multi-ciliated epithelial cell differentiation [GO:1903251]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to ...
cell division [GO:0051301]; cilium assembly [GO:0060271]; mitotic cell cycle [GO:0000278]; mitotic cell cycle phase transition [GO:0044772]; multi-ciliated epithelial cell differentiation [GO:1903251]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; response to xenobiotic stimulus [GO:0009410]
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GO - Molecular function (MF):
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]...
cyclin-dependent protein serine/threonine kinase regulator activity [GO:0016538]
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GO - Cellular component (CC):
cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]...
cyclin A2-CDK2 complex [GO:0097124]; cyclin-dependent protein kinase holoenzyme complex [GO:0000307]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]
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CCNO
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*NOTE: the Kaplan plots were collected from OncoLnc