DegronMD - P22735(TGM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S24C	TCGA-33-4566	LUSC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.7541
p.S24C	DO26790	LUSC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.7541
p.V9M	TCGA-63-A5MW	LUSC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.V9M	DO219169	LUSC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.T22M	TCGA-A6-5665	COAD	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.7423
p.T22M	DO9756	COAD	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.7423
p.T22M	DO52487	COCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.7423
p.R36H	TCGA-AP-A051	UCEC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.R36H	DO42673	UCEC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.R34C	TCGA-B5-A1MX	UCEC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	TCGA-F4-6459	COAD	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	DO7843	COAD	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	DO41999	UCEC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	SIDM00331	B-Lymphoblastic Leukemia	GDSC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	ACH-000020	Leukemia	CCLE	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R34C	MHH-CALL-2	haematopoietic and lymphoid tissue	COSMIC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.R36C	TCGA-DK-A1AC	BLCA	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.R36C	DO514	BLCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.0556
p.G14C	TCGA-EE-A181	SKCM	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1944
p.G14C	DO37444	SKCM	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1944
p.R34H	DO230311	COCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.1111
p.P16T	DO229026	LICA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation rewiring degron network	0.25
p.T21A	SIDM01062	Breast Carcinoma	GDSC	PPTTPSPE	DEG_SCF_FBW7_2	19:26	Mutation altering degron motif	0.6028

Kaplan plot for TGM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGM1

UniProt ID: P22735

Entrez ID: 7051

Protein name: Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGM1 in