DegronMD

Uniprot ID: P22735

Source protein: Protein-glutamine gamma-glutamyltransferase K

Source gene: TGM1

Class: DEG_SCF_FBW7_2

Location: 19:26

E3 ligase: FBXW7

DEGRON score: 0.8823

ASA_SCORE: 95.2

COIL: 0.9713

CONS_SCORE: 0.2429

DSS_SCORE: 0.8614

HELIX: 0.0108

FCONS_SCORE: 0.8889

RIG_SCORE: 0.5402

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S24C	TCGA-33-4566	LUSC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.7541
p.S24C	DO26790	LUSC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.7541
p.V9M	TCGA-63-A5MW	LUSC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.V9M	DO219169	LUSC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.T22M	TCGA-A6-5665	COAD	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.7423
p.T22M	DO9756	COAD	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.7423
p.T22M	DO52487	COCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.7423
p.R36H	TCGA-AP-A051	UCEC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.R36H	DO42673	UCEC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.R34C	TCGA-B5-A1MX	UCEC	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	TCGA-F4-6459	COAD	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	DO7843	COAD	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	DO41999	UCEC	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	SIDM00331	B-Lymphoblastic Leukemia	GDSC	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	ACH-000020	Leukemia	CCLE	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R34C	MHH-CALL-2	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.R36C	TCGA-DK-A1AC	BLCA	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.R36C	DO514	BLCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.0556
p.G14C	TCGA-EE-A181	SKCM	TCGA	PPTTPSPE	DEG_SCF_FBW7_2	0.1944
p.G14C	DO37444	SKCM	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.1944
p.R34H	DO230311	COCA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.1111
p.P16T	DO229026	LICA	ICGC	PPTTPSPE	DEG_SCF_FBW7_2	0.25
p.T21A	SIDM01062	Breast Carcinoma	GDSC	PPTTPSPE	DEG_SCF_FBW7_2	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22735	Protein-glutamine gamma-glutamyltransferase K	DEG_SCF_FBW7_2	19:26	PPTTPSPE	FBXW7	0.8823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons