DegronMD - P23109(AMPD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L121I	TCGA-55-A4DG	LUAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.1667
p.N116T	TCGA-A5-A2K5	UCEC	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.3056
p.F109V	TCGA-AA-3984	COAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7068
p.T124P	TCGA-AX-A1CE	UCEC	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.0833
p.T114I	TCGA-EE-A2GN	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7078
p.T114I	TCGA-FR-A726	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7078
p.A103S	TCGA-FG-A711	LGG	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.3056
p.R108C	TCGA-HU-A4GN	STAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8301
p.E102D	TCGA-TM-A84Q	LGG	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.2778
p.P120S	TCGA-Z2-A8RT	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.1944
p.Q116H	DO51900	BLCA	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.3056
p.V112M	DO52505	EOPC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7208
p.P113T	DO229036	LICA	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7031
p.D100H	DO52194	LIHC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.2222
p.D114N	DO224563	LUSC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.6932
p.Q119H	DO26971	LUSC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.2222
p.S105L	DO50299	SKCM	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7667
p.I99V	DO42033	UCEC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.1944
p.R108H	SIDM00683	Prostate Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM00088	Prostate Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM00660	Colorectal Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM01017	B-Lymphoblastic Leukemia	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM00505	Pancreatic Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.R108H	SIDM01228	Melanoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8244
p.L121Q	SIDM00845	Burkitt's Lymphoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.1667
p.K107R	SIDM00845	Burkitt's Lymphoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.7237
p.R112W	SIDM00650	Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8634
p.R112W	SIDM01133	Other Solid Cancers	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8634
p.R112W	SIDM01681	Non-Cancerous	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8634
p.R104W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8634
p.R104W	NCI-H2342	lung	COSMIC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation altering degron motif	0.8634
p.R100W	ACH-000951	Lung Cancer	CCLE	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.2222
p.R100W	NCI-H2342	lung	COSMIC	SSSPTYQTVPDF	DEG_COP1_1	104:115	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMPD1

UniProt ID: P23109

Entrez ID: 270

Protein name: AMP deaminase 1 (EC 3.5.4.6) (AMP deaminase isoform M) (Myoadenylate deaminase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMPD1 in