DegronMD

Uniprot ID: P23109

Source protein: AMP deaminase 1

Source gene: AMPD1

Class: DEG_COP1_1

Location: 104:115

E3 ligase: COP1

DEGRON score: 0.9527

ASA_SCORE: 75.9333

COIL: 0.8278

CONS_SCORE: 0.2692

DSS_SCORE: 0.3449

HELIX: 0.0508

FCONS_SCORE: 0.9632

RIG_SCORE: 0.7688

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L121I	TCGA-55-A4DG	LUAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.1667
p.N116T	TCGA-A5-A2K5	UCEC	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.3056
p.F109V	TCGA-AA-3984	COAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.7068
p.T124P	TCGA-AX-A1CE	UCEC	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.0833
p.T114I	TCGA-EE-A2GN	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.7078
p.T114I	TCGA-FR-A726	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.7078
p.A103S	TCGA-FG-A711	LGG	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.3056
p.R108C	TCGA-HU-A4GN	STAD	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.8301
p.E102D	TCGA-TM-A84Q	LGG	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.2778
p.P120S	TCGA-Z2-A8RT	SKCM	TCGA	SSSPTYQTVPDF	DEG_COP1_1	0.1944
p.Q116H	DO51900	BLCA	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.3056
p.V112M	DO52505	EOPC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.7208
p.P113T	DO229036	LICA	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.7031
p.D100H	DO52194	LIHC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.2222
p.D114N	DO224563	LUSC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.6932
p.Q119H	DO26971	LUSC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.2222
p.S105L	DO50299	SKCM	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.7667
p.I99V	DO42033	UCEC	ICGC	SSSPTYQTVPDF	DEG_COP1_1	0.1944
p.R108H	SIDM00683	Prostate Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM00088	Prostate Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM00660	Colorectal Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM01017	B-Lymphoblastic Leukemia	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM00505	Pancreatic Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.R108H	SIDM01228	Melanoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8244
p.L121Q	SIDM00845	Burkitt's Lymphoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.1667
p.K107R	SIDM00845	Burkitt's Lymphoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.7237
p.R112W	SIDM00650	Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8634
p.R112W	SIDM01133	Other Solid Cancers	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8634
p.R112W	SIDM01681	Non-Cancerous	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8634
p.R104W	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SSSPTYQTVPDF	DEG_COP1_1	0.8634
p.R104W	NCI-H2342	lung	COSMIC	SSSPTYQTVPDF	DEG_COP1_1	0.8634
p.R100W	ACH-000951	Lung Cancer	CCLE	SSSPTYQTVPDF	DEG_COP1_1	0.2222
p.R100W	NCI-H2342	lung	COSMIC	SSSPTYQTVPDF	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSPTYQTVPDF

Degron related mutations and impact score

Drug responses associated with AMPD1 mutations

All proteins holding degron of SSSPTYQTVPDF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23109	AMP deaminase 1	DEG_COP1_1	104:115	SSSPTYQTVPDF	COP1	0.9527	More...