DegronMD - P23467(PTPRB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1051D	TCGA-AA-3811	COAD	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.3056
p.D1065N	TCGA-AA-3864	COAD	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.R1046H	TCGA-AJ-A3BH	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.R1046H	TCGA-AX-A0J1	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.E1068K	TCGA-AO-A03M	BRCA	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.0833
p.R1046C	TCGA-AP-A1DV	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.D1063A	TCGA-EK-A2PL	CESC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.2222
p.S1048T	DO50224	LGG	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation substituting flanking lysine	0.3333
p.N1053K	DO228948	LICA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.6918
p.S1048I	DO27247	LUSC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation substituting flanking lysine	0.3333
p.P1044L	DO220900	MELA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1111
p.P1044S	DO220900	MELA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1111
p.V1046I	DO229446	SKCA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.G1069E	DO37839	SKCM	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation blocking phosphorylation signal	0.5
p.K1061T	DO43907	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.2778
p.V1065A	DO41235	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.S1048R	DO42673	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation substituting flanking lysine	0.3333
p.S1048R	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation substituting flanking lysine	0.3333
p.I1064S	DO41331	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1944
p.T1056I	SIDM00427	Ewing's Sarcoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7078
p.T1056I	SIDM00258	Neuroblastoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7078
p.T1056I	SIDM00659	Glioblastoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7078
p.T1056I	SIDM00594	Acute Myeloid Leukemia	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7078
p.T1056I	SIDM00882	Breast Carcinoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7078
p.T1055M	ACH-000151	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7423
p.T1055M	JM1	haematopoietic and lymphoid tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7423
p.S1053R	ACH-000362	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.S1053R	ACH-000500	Head and Neck Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.S1053R	ACH-001574	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.S1053R	ACH-001642	Lymphoma	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.S1053R	SCC-3	haematopoietic and lymphoid tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.S1053R	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7427
p.I1045N	ACH-000611	Lymphoma	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1389
p.D1052N	ACH-001552	Skin Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.6932
p.D1052N	MCC26	skin	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.6932
p.S1046P	ACH-002015	Eye Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.1667
p.Y1068H	ACH-002099	Bone Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.0833
p.Y1068H	CS1	bone	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.0833
p.S1068N	MFE-319	endometrium	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.0833
p.S1068G	YAPC	pancreas	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation rewiring degron network	0.0833
p.M1059I	PANC-04-03	pancreas	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.7618
p.V1056L	NCI-H1915	lung	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	1052:1059	Mutation altering degron motif	0.6765

Kaplan plot for PTPRB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRB

UniProt ID: P23467

Entrez ID: 5787

Protein name: Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRB in