DegronMD

Uniprot ID: P23467

Source protein: Receptor-type tyrosine-protein phosphatase beta

Source gene: PTPRB

Class: DEG_SCF_SKP2-CKS1_1

Location: 1052:1059

E3 ligase: SKP2,CSK1

DEGRON score: 0.6482

ASA_SCORE: 57.325

COIL: 0.683

CONS_SCORE: 0.5436

DSS_SCORE: 0.3828

HELIX: 0.0145

FCONS_SCORE: 1.0546

RIG_SCORE: 0.7757

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1051D	TCGA-AA-3811	COAD	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D1065N	TCGA-AA-3864	COAD	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R1046H	TCGA-AJ-A3BH	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R1046H	TCGA-AX-A0J1	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E1068K	TCGA-AO-A03M	BRCA	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.R1046C	TCGA-AP-A1DV	UCEC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.D1063A	TCGA-EK-A2PL	CESC	TCGA	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S1048T	DO50224	LGG	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.3333
p.N1053K	DO228948	LICA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.6918
p.S1048I	DO27247	LUSC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.3333
p.P1044L	DO220900	MELA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P1044S	DO220900	MELA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V1046I	DO229446	SKCA	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G1069E	DO37839	SKCM	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.5
p.K1061T	DO43907	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.V1065A	DO41235	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.S1048R	DO42673	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.3333
p.S1048R	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.3333
p.I1064S	DO41331	UCEC	ICGC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.T1056I	SIDM00427	Ewing's Sarcoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1056I	SIDM00258	Neuroblastoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1056I	SIDM00659	Glioblastoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1056I	SIDM00594	Acute Myeloid Leukemia	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1056I	SIDM00882	Breast Carcinoma	GDSC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7078
p.T1055M	ACH-000151	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7423
p.T1055M	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7423
p.S1053R	ACH-000362	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S1053R	ACH-000500	Head and Neck Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S1053R	ACH-001574	Leukemia	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S1053R	ACH-001642	Lymphoma	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S1053R	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S1053R	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7427
p.I1045N	ACH-000611	Lymphoma	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.D1052N	ACH-001552	Skin Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D1052N	MCC26	skin	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.6932
p.S1046P	ACH-002015	Eye Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Y1068H	ACH-002099	Bone Cancer	CCLE	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.Y1068H	CS1	bone	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S1068N	MFE-319	endometrium	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S1068G	YAPC	pancreas	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.M1059I	PANC-04-03	pancreas	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.7618
p.V1056L	NCI-H1915	lung	COSMIC	FEDLTPGK	DEG_SCF_SKP2-CKS1_1	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FEDLTPGK

Degron related mutations and impact score

Drug responses associated with PTPRB mutations

All proteins holding degron of FEDLTPGK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23467	Receptor-type tyrosine-protein phosphatase beta	DEG_SCF_SKP2-CKS1_1	1052:1059	FEDLTPGK	SKP2,CSK1	0.6482	More...