DegronMD - P23470(PTPRG)

PTPRG

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I883V	TCGA-77-8148	LUSC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation rewiring degron network	0.1667
p.P895L	TCGA-DA-A1I8	SKCM	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.6471
p.I881S	TCGA-DX-A6Z2	SARC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation rewiring degron network	0.1111
p.P897S	TCGA-EO-A3AV	UCEC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.5641
p.K892R	TCGA-FW-A3R5	SKCM	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.6126
p.F906V	DO8730	COAD	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation blocking phosphorylation signal	0.5278
p.G897R	DO233272	GACA	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.7568
p.T902A	DO27112	LUSC	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation blocking ubiquitination signal	0.6389
p.P898H	DO42472	UCEC	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation rewiring degron network	0.3056
p.Y906C	SIDM00148	Breast Carcinoma	GDSC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation blocking phosphorylation signal	0.5278
p.Y906C	MCF7	breast	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation blocking phosphorylation signal	0.5278
p.A894T	HEC-1	endometrium	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.7139
p.Y892F	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	889:897	Mutation altering degron motif	0.7528

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*NOTE: the Kaplan plots were collected from OncoLnc