DegronMD

Uniprot ID: P23470

Source protein: Receptor-type tyrosine-protein phosphatase gamma

Source gene: PTPRG

Class: DEG_APCC_DBOX_1

Location: 889:897

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7115

ASA_SCORE: 43.8778

COIL: 0.5046

CONS_SCORE: 0.6295

DSS_SCORE: 0.4512

HELIX: 0.0108

FCONS_SCORE: 0.9705

RIG_SCORE: 0.7401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I883V	TCGA-77-8148	LUSC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	0.1667
p.P895L	TCGA-DA-A1I8	SKCM	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	0.6471
p.I881S	TCGA-DX-A6Z2	SARC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	0.1111
p.P897S	TCGA-EO-A3AV	UCEC	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	0.5641
p.K892R	TCGA-FW-A3R5	SKCM	TCGA	SRVKLRPLP	DEG_APCC_DBOX_1	0.6126
p.F906V	DO8730	COAD	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	0.5278
p.G897R	DO233272	GACA	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	0.7568
p.T902A	DO27112	LUSC	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	0.6389
p.P898H	DO42472	UCEC	ICGC	SRVKLRPLP	DEG_APCC_DBOX_1	0.3056
p.Y906C	SIDM00148	Breast Carcinoma	GDSC	SRVKLRPLP	DEG_APCC_DBOX_1	0.5278
p.Y906C	MCF7	breast	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	0.5278
p.A894T	HEC-1	endometrium	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	0.7139
p.Y892F	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	SRVKLRPLP	DEG_APCC_DBOX_1	0.7528

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23470	Receptor-type tyrosine-protein phosphatase gamma	DEG_APCC_DBOX_1	889:897	SRVKLRPLP	APC,CDC20,FZR1	0.7115	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons