DegronMD - P23528(CFL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D9N	TCGA-C5-A7UC	CESC	TCGA	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking ubiquitination signal	0.6944
p.M18L	TCGA-ED-A7XP	LIHC	TCGA	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.3056
p.M18L	DO48562	LIHC	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.3056
p.R15H	DO7855	COAD	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation altering degron motif	0.8244
p.E25K	DO14286	HNSC	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.5556
p.H8Y	DO47337	SKCM	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.6667
p.V19M	DO38711	STAD	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking ubiquitination signal	0.7222
p.A18V	DO42280	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.3056
p.R15C	DO41871	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation altering degron motif	0.8301
p.R15C	DO43891	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation altering degron motif	0.8301
p.G4D	SIDM00524	Small Cell Lung Carcinoma	GDSC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.5556
p.G4D	DMS-79	lung	COSMIC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.5556
p.R21C	SIDM00783	Colorectal Carcinoma	GDSC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.2222
p.R21C	HCT-116	large intestine	COSMIC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.2222
p.R4C	ACH-000971	Colon/Colorectal Cancer	CCLE	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.5556
p.R4C	HCT-116	large intestine	COSMIC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation blocking phosphorylation signal	0.5556
p.T16A	SK-MEL-2	skin	COSMIC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation altering degron motif	0.7139
p.H18Y	A704	kidney	COSMIC	IKVFND	LIG_APCC_ABBA_1	12:17	Mutation rewiring degron network	0.3056

Kaplan plot for CFL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CFL1

UniProt ID: P23528

Entrez ID: 1072

Protein name: Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CFL1 in