DegronMD

Uniprot ID: P23528

Source protein: Cofilin-1

Source gene: CFL1

Class: LIG_APCC_ABBA_1

Location: 12:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7225

ASA_SCORE: 56.0167

COIL: 0.0202

CONS_SCORE: 0.5437

DSS_SCORE: 0.2532

HELIX: 0.9793

FCONS_SCORE: 1.2674

RIG_SCORE: 0.8569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D9N	TCGA-C5-A7UC	CESC	TCGA	IKVFND	LIG_APCC_ABBA_1	0.6944
p.M18L	TCGA-ED-A7XP	LIHC	TCGA	IKVFND	LIG_APCC_ABBA_1	0.3056
p.M18L	DO48562	LIHC	ICGC	IKVFND	LIG_APCC_ABBA_1	0.3056
p.R15H	DO7855	COAD	ICGC	IKVFND	LIG_APCC_ABBA_1	0.8244
p.E25K	DO14286	HNSC	ICGC	IKVFND	LIG_APCC_ABBA_1	0.5556
p.H8Y	DO47337	SKCM	ICGC	IKVFND	LIG_APCC_ABBA_1	0.6667
p.V19M	DO38711	STAD	ICGC	IKVFND	LIG_APCC_ABBA_1	0.7222
p.A18V	DO42280	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	0.3056
p.R15C	DO41871	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	0.8301
p.R15C	DO43891	UCEC	ICGC	IKVFND	LIG_APCC_ABBA_1	0.8301
p.G4D	SIDM00524	Small Cell Lung Carcinoma	GDSC	IKVFND	LIG_APCC_ABBA_1	0.5556
p.G4D	DMS-79	lung	COSMIC	IKVFND	LIG_APCC_ABBA_1	0.5556
p.R21C	SIDM00783	Colorectal Carcinoma	GDSC	IKVFND	LIG_APCC_ABBA_1	0.2222
p.R21C	HCT-116	large_intestine	COSMIC	IKVFND	LIG_APCC_ABBA_1	0.2222
p.R4C	ACH-000971	Colon/Colorectal Cancer	CCLE	IKVFND	LIG_APCC_ABBA_1	0.5556
p.R4C	HCT-116	large_intestine	COSMIC	IKVFND	LIG_APCC_ABBA_1	0.5556
p.T16A	SK-MEL-2	skin	COSMIC	IKVFND	LIG_APCC_ABBA_1	0.7139
p.H18Y	A704	kidney	COSMIC	IKVFND	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23528	Cofilin-1	LIG_APCC_ABBA_1	12:17	IKVFND	APC,CDC20,FZR1	0.7225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons